针对成人无症状细菌尿的查:美国预防服务工作组的最新证据报告和系统审查
Jillian T Henderson1, Elizabeth M Webber1, Sarah I Bean1
1Center for Health Research, Kaiser Permanente Research Affiliates Evidence-based Practice Center, Kaiser Permanente, Portland, Oregon.
JAMA
|September 25, 2019
概括
在孕妇中查无症状细菌性尿症 (ASB) 可能会减少发炎和低出生体重. 然而,在非怀孕的成年人中,ASB治疗没有益处,对危害的证据有限.
科学领域:
- 尿道病学
- 传染性疾病
- 预防医学
背景情况:
- 无症状细菌尿 (ASB) 查可以识别受益于治疗的患者,以预防感染.
- 美国预防服务工作组要求对ASB查和治疗的好处和危害进行系统审查.
研究的目的:
- 对包括孕妇在内的成年人进行ASB查和治疗的益处和危害进行系统审查.
- 为美国预防服务工作组提供指导方针.
主要方法:
- 搜索了MEDLINE,PubMed和Cochrane图书馆的随机临床试验 (RCT) 和ASB查和治疗的观察性研究.
- 包括未经选择的无症状个体的益处和危害研究.
- 进行了随机效应对益的元分析.
主要成果:
- 在接受查的孕妇中,两项队列研究表明肺炎减少 (RR 0. 30).
- 12项试验显示,在怀孕期间进行ASB查和治疗可以减少发炎 (RR 0.24) 和低出生体重 (RR 0.64).
- 五项RCT在非孕妇成年人中没有发现ASB治疗的显著益处.
结论:
- 在怀孕期间的ASB查和治疗减少了肌炎和低出生体重,但证据已过时.
- 在非怀孕的成年人中没有发现ASB治疗的益处.
- 关于ASB查和治疗的危害的证据有限.
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