氨基:主要组异环的合成
Liu Leo Liu1, Jiliang Zhou1, Levy L Cao1
1Department of Chemistry , University of Toronto , 80 St. George Street , Toronto , Ontario M5S 3H6 , Canada.
合成了具有紧张的三环-碳- (AlCP) 的新氨基烯. 这些化合物经历环开放和环扩大反应,形成新的主要组异环.
科学领域:
- 有机金属化学
- 主要组化学
- 合成化学
背景情况:
- (I) 复合物是反应性中间体.
- 素是合成中的多功能构建块.
- 由于应力,三环常常表现出独特的反应性.
研究的目的:
- 合成含有三个成员的AlCP环的新型氨酸.
- 调查这些压力AlCP系统的反应性和芳香性.
- 探索新的主要组异环的形成.
主要方法:
- 一个 (I) 复合物和基因之间的 [1 + 2] 循环添加反应.
- 结晶胺化合物的合成.
- 密度函数理论 (DFT) 计算用于机械洞察.
- 与各种基质 (酒精,异化物,碳素,基,基) 进行反应,以研究环开放和环扩大.
主要成果:
- 胺二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二
- 在AlCP环中的2π电子芳香度的计算证据.
- 在质子化时,化合物3的环开放产生素4.
- 用各种试剂 (CyNC,BAC,Se,Ph2CO,PhCHCHCOPh,PhCN) 轻松扩大化合物3的环,形成前所未有的主组异环5-10.
- 在新形成的异环中保存CP不和键.
结论:
- 通过 [1 + 2] 循环添加,可以获得带有压力AlCP环的氨酸.
- 该环具有芳香性质,并经历各种环开放和环扩大反应.
- 这种化学反应提供了具有完整CP键的新型主组异环.
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