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Updated: Jan 6, 2026

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通过 (III) 希夫基复合物抑制粉样β聚合:一种计算和实验方法

Aysenur Iscen1, Christopher R Brue1, Kaleigh F Roberts1

  • 1Department of Chemistry, Molecular Biosciences, Neurobiology, Biomedical Engineering, and Radiology, Chemical and Biological Engineering , Northwestern University , 2145 Sheridan Road , Evanston , Illinois 60208-3113 , United States.

Journal of the American Chemical Society
|October 2, 2019
PubMed
概括

这项研究引入了一种新型的 ((III) 希夫基复合物,可以有效抑制粉样β (Aβ) 聚合. 该复合物减少β片形成并破坏现有聚合物的稳定,显示为粉样蛋白疾病的治疗剂的潜力.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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