诱导和利用肝癌治疗的弱点
Cun Wang1,2, Serena Vegna3, Haojie Jin1,2
1State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Nature
|October 4, 2019
概括
针对DNA复制激酶CDC7诱导肝癌细胞衰老. 然后抗抑郁药塞特拉林通过阻断mTOR信号来选择性地杀死这些细胞,
科学领域:
- 癌症学
- 分子生物学
- 药理学
背景情况:
- 肝癌,尤其是肝细胞癌的有效治疗方法有限.
- 像索拉费尼布这样的现有疗法提供了适度的益处.
- 诱导细胞衰老随后发生衰老是一种潜在的治疗策略.
研究的目的:
- 确定肝癌的新疗法目标.
- 研究CDC7抑制在诱导肝癌细胞衰老中的作用.
- 发现选择性地消除衰老的肝癌细胞的药物.
主要方法:
- 一个以基因组为重点的基因选, 以确定CDC7为目标.
- 一个化学选识别老化剂, 导致塞特拉林.
- 抑制了CDC7和mTOR信号通路.
- 肝癌的实体小鼠模型.
主要成果:
- 在TP53突变的肝癌细胞中,药理上抑制CDC7可选择性地诱导衰老.
- 塞特拉林被认为是一种老化剂,可以选择性地杀死CDC7抑制的老化细胞.
- 联合抑制CDC7和mTOR信号导致持续的mTOR抑制和亡.
- 组合治疗显著减少了小鼠模型中的瘤生长.
结论:
- 针对CDC7诱导衰老, 随后使用诸如塞特拉林之类的药物进行衰老, 是治疗肝癌的有希望的策略.
- 结合CDC7和mTOR抑制显示出显著的抗瘤功效.
- 利用诱导的脆弱性为肝癌治疗提供了一种新的治疗方法.
更多相关视频
09:03Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula
Published on: January 26, 2024
645
12:24A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
5.9K
相关概念视频
Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
Combination Therapies and Personalized Medicine
5.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
Cancer Therapies
9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K
