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Updated: Jan 6, 2026

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
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低氧激活的PEGylated条件Aptamer/抗体用于改善特异性的癌症成像

Fang Zhou1, Ting Fu1, Qin Huang1

  • 1Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, and Aptamer Engineering Center of Hunan Province , Hunan University , Changsha 410082 , P. R. China.

Journal of the American Chemical Society
|October 5, 2019
PubMed
概括

这项研究引入了一种条件性合酶,它只在低氧瘤环境中激活,从而减少癌症诊断和治疗的瘤外效应. 这种低氧激活的探针增强了针对癌症的治疗策略.

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Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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