通过神经刺激和REST调节寿命
Joseph M Zullo1, Derek Drake1, Liviu Aron1
1Department of Genetics, Harvard Medical School, Boston, MA, USA.
Nature
|October 18, 2019
概括
科学家发现减少神经刺激和REST基因是延长寿命的关键. 这种保存机制包括调节大脑活动以促进物种长寿.
科学领域:
- 神经科学
- 遗传学
- 老龄化研究
背景情况:
- 人类寿命延长的机制在很大程度上是未知的.
- 神经活动及其调节与衰老过程有关.
研究的目的:
- 研究人类延长寿命的分子和神经机制.
- 通过神经电路活动来确定调节寿命的保护途径.
主要方法:
- 在人类大脑皮层的转录组分析.
- 在Caenorhabditis elegans和小鼠的寿命研究.
- 对REST及其类型的基因表达分析.
- 在老化模型中研究神经刺激和抑制.
主要成果:
- 人类的寿命延长与神经刺激和突触功能下调的基因相关.
- 抑制神经刺激可以延长C. elegans的寿命.
- 在长寿的人群中,转录因子REST被上调,并抑制与激发相关的基因.
- 在小鼠中,REST缺乏会增加神经元刺激性并加速衰老.
- 在C. elegans中,REST正位子 (SPR-3,SPR-4) 调节激发和寿命.
- 减少FOXO1/DAF-16的激发和REST激活是保存寿命的途径.
结论:
- 神经电路活动,特别是减少激发,是延长寿命的保存机制.
- 转录因子REST在调节这种保存的衰老途径中起着至关重要的作用.
- 针对神经刺激提供了一种促进长寿的潜在策略.
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