Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genomic DNA in Prokaryotes00:46

Genomic DNA in Prokaryotes

48.0K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
48.0K
DNA Packaging00:58

DNA Packaging

111.8K
Overview
111.8K
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

52.0K
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
52.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Plasma-SELEX for Acute Myocardial Infarction Biomarker Discovery and Diagnosis.

Analytical chemistry·2026
Same author

Reprogramming Aromatic Camptothecins into TOP1 Degraders via Synergistic Hydrophobic Tagging and Supramolecular Assembly.

Journal of the American Chemical Society·2026
Same author

Author Correction: DNA nanodevices detect an acidic nanolayer on the lysosomal surface.

Nature cell biology·2026
Same author

Receptor-Tethered Cytosolic Modulators Enable Spatial Control of Cell Signaling Specificity.

ACS nano·2026
Same author

Covalent Photo-Aptamer Tagging (CPAT) for Single-Cell Multiplexing and Chemical Transcriptomic Screens.

Analytical chemistry·2026
Same author

Modular nucleic acid-based construct for delivery of immunostimulatory agonists and oncogene-silencing oligonucleotides in tumours.

Nature biomedical engineering·2026

相关实验视频

Updated: Jan 5, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

15.0K

细胞膜定DNA纳米平台用于编程细胞相互作用

Jin Li1, Kanyu Xun1, Ke Pei1

  • 1Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, and Aptamer Engineering Center of Hunan Province , Hunan University , Changsha , Hunan 410082 , China.

Journal of the American Chemical Society
|October 19, 2019
PubMed
概括

研究人员使用3DDNA支架设计了细胞表面, 以实现稳定的细胞连接. 这种DNA探针策略通过改善膜定和目标可访问性来增强细胞通信研究.

更多相关视频

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

4.7K
Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
07:50

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Published on: November 25, 2015

14.8K

相关实验视频

Last Updated: Jan 5, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

15.0K
DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

4.7K
Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
07:50

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Published on: November 25, 2015

14.8K

科学领域:

  • 生物技术
  • 分子工程
  • 细胞生物学

背景情况:

  • 细胞与细胞之间的相互作用对于生物功能至关重要,并且由细胞表面分子介导.
  • 由于细胞膜的动态性,对受控相互作用的细胞表面的设计具有挑战性.

研究的目的:

  • 开发一种用于控制细胞相互作用的DNA探针的细胞表面工程的新策略.
  • 提高膜固功能模块的稳定性和可访问性.

主要方法:

  • 使用三维 (3D) 两形金字塔DNA作为DNA探测器构建的支架.
  • 开发了一种生物相容和多功能方法来将DNA探针固定在细胞表面.
  • 研究了DNA探针结构对膜定稳定性和目标可访问性的影响.

主要成果:

  • 与线性DNA结构相比,3D金字塔式DNA探测器显示了显著更高的膜定稳定性 (近100倍).
  • 使用金字塔式DNA探针实现了更高的目标可访问性 (大约2.5倍).
  • 展示了特定,有效和可调节的细胞-细胞连接,突出显示了细胞间通信的近距离的重要性.

结论:

  • 开发的DNA探针策略为工程细胞表面提供了一个生物相容,稳定和多功能平台.
  • 这种方法为研究多细胞通信网络提供了强大的可设计纳米平台.
  • 这些发现强调了DNA纳米技术在促进细胞工程和细胞间通信研究方面的潜力.