痴呆症的诊断和治疗:综述
Zoe Arvanitakis1,2, Raj C Shah1,3, David A Bennett1,2
1Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.
JAMA
|October 23, 2019
概括
痴呆症在全球影响着数以百万计的人, 诊断包括病史,认知检查和成像,而治疗则结合非药物和药物策略,有效性有限.
科学领域:
- 神经学
- 老年病学
- 认知科学
背景情况:
- 全球有4700万人患有痴呆症, 预计到2050年将达到1.31亿.
- 阿尔茨海默病是导致痴呆的主要病因,
- 痴呆症通常涉及多种神经病理,通常是阿尔茨海默病与脑血管疾病.
研究的目的:
- 描述痴呆症的诊断过程.
- 讨论目前痴呆症的治疗策略.
- 突出痴呆症和阿尔茨海默病的流行和影响.
主要方法:
- 诊断依赖于患者病史,认知和精神状况检查以及家庭/朋友的证据.
- 神经心理测试,身体检查,脑神经成像,脑脊液测试和基因测试有助于诊断.
- 治疗包括非药物方法 (认知活动,运动,社交) 和药物选择.
主要成果:
- 诊断痴呆症需要全面评估以确定认知能力下降和功能障碍.
- 常见的诊断工具包括认知查问卷,心理状态检查和神经影像.
- 药物治疗可以缓解阿尔茨海默病和帕金森病等疾病的症状.
结论:
- 痴呆症的诊断是复杂的,通常需要多方面的方法.
- 有效的痴呆症管理包括非药物和药物干预.
- 虽然有治疗方法, 但效果仍然有限, 需要进一步研究.
相关概念视频
Dementia
476
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
476
Alzheimer's Disease: Overview
1.5K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.5K
Alzheimer's Disease: Treatment
731
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
731
Parkinson's Disease: Overview
1.6K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
1.6K
Diagnostic and Statistical Manual of Mental Disorders (DSM)
835
The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
835
Dysrhythmias VII: Nursing Management of Dysrhythmias
300
Nursing management of dysrhythmias involves the following:AssessmentSubjective Assessment:The initial step involves gathering patient-reported symptoms such as dizziness, palpitations, and chest discomfort. It is crucial to collect a detailed history, including previous heart conditions, current medication use, and lifestyle factors like caffeine and alcohol consumption.Objective Assessment:This involves observing clinical signs such as jugular venous distention, cool and pale skin, and...
300


