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Updated: Jan 5, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

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选择性抗剂与酸盐受体结合的结构基础

Matthias Haffke1,2, Dominique Fehlmann3, Gabriele Rummel4

  • 1Chemical Biology & Therapeutics, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland. matthias.haffke@novartis.com.

Nature
|October 25, 2019
PubMed
概括

研究人员确定了酸盐受体SUCNR1的晶体结构,揭示了其无活性状态和对抗剂结合的洞察力. 这些结构信息有助于开发针对性治疗与酸盐信号相关的疾病.

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