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VISTA是PSGL-1的酸性pH选择性连接体

Robert J Johnston1, Linhui Julie Su2, Jason Pinckney3

  • 1Immuno-Oncology Discovery, Bristol-Myers Squibb, Redwood City, CA, USA. robert.johnston@bms.com.

Nature
|October 25, 2019
PubMed
概括

在酸性pH下,瘤微环境通过VISTA与PSGL-1结合来抑制T细胞. 阻断这种相互作用会逆转免疫抑制,

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