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Updated: Jan 5, 2026

Characterizing Mutational Load and Clonal Composition of Human Blood
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健康和肝硬化的人体突变和克隆动态

Simon F Brunner1, Nicola D Roberts1, Luke A Wylie1

  • 1Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.

Nature
|October 25, 2019
PubMed
概括

与正常肝脏相比,慢性肝脏疾病显著增加肝细胞的突变负担和结构变异. 这些体质突变跟踪肝病的进展,毒性和再生,为肝细胞癌的发展提供了洞察力.

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