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Updated: Jan 4, 2026

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反复发生的非编码U1snRNA突变导致SHH骨髓母细胞瘤的神秘拼接

Hiromichi Suzuki1,2, Sachin A Kumar1,2,3, Shimin Shuai4,5

  • 1The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.

Nature
|October 31, 2019
PubMed
概括

高度重复的U1结合体小核RNA (snRNA) 突变驱动Sonic刺细胞瘤. 这些非编码RNA突变会破坏结合,影响瘤基因和瘤抑制剂,从而成为潜在的治疗点.

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