对开始性乳头瘤病毒的免疫力可以预防皮肤癌
John D Strickley1,2,3, Jonathan L Messerschmidt1, Mary E Awad1
1Center for Cancer Immunology and Cutaneous Biology Research Center, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
对常见的皮肤病毒 (β人类乳头瘤病毒或β-HPV) 的免疫力可以预防皮肤癌. 这种免疫的丧失, 而不是病毒本身, 导致免疫抑制个体的皮肤癌风险增加.
科学领域:
- 免疫学
- 癌症学
- 病毒学
背景情况:
- 免疫抑制显著增加癌症的风险,特别是与β-HPV相关的皮肤癌.
- 皮肤癌的确切作用尚不清楚,之前的研究缺乏明确的致病证据.
研究的目的:
- 研究T细胞对开始性乳头瘤病毒的免疫在抑制皮肤癌中的作用.
- 确定抗病毒免疫或直接病毒瘤发生的损失是否会增加免疫抑制患者的皮肤癌风险.
主要方法:
- 用1型小鼠乳头瘤病毒 (MmuPV1) 对免疫能力强的小鼠进行定居.
- 在MmuPV1免疫小鼠中对化学或紫外线诱导的皮肤致癌性保护的评估 (通过自然感染,T细胞转移或疫苗接种).
- 在人体皮肤癌和健康皮肤中分析β-HPV活性和负荷的RNA和DNA in situ杂交;分析β-HPV的CD8+T细胞激活.
主要成果:
- 在依赖CD8+T细胞的小鼠中,对MmuPV1的免疫力提供了对皮肤致癌的保护.
- 与相邻的健康皮肤相比,人类皮肤癌的β-HPV活性和负荷降低,表明对感染细胞的免疫选择.
- 来自健康人体皮肤的CD8+ T细胞识别了β-HPV E7.
结论:
- 对开始性乳头瘤病毒的T细胞免疫力抑制了免疫能力较强的主体的皮肤癌.
- 这种保护性免疫的丧失,而不是直接的病毒瘤发生,是免疫抑制个体皮肤癌风险增加的主要原因.
- 增强对开始性β-HPV的免疫力是预防皮肤癌的潜在策略.
更多相关视频
13:41Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
07:43Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples
Published on: July 29, 2017
相关概念视频
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Mechanisms of Retrovirus-induced Cancers
Cancer Prevention
Some...
Papillary Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)