皮层和胸膜连接的层次组织
Julie A Harris1, Stefan Mihalas2, Karla E Hirokawa2
1Allen Institute for Brain Science, Seattle, WA, USA. julieha@alleninstitute.org.
Nature
|November 1, 2019
概括
研究人员使用新的追踪器实验绘制了老鼠大脑连接. 他们发现了大脑皮层网络中的一般规则和浅层次结构, 揭示了大脑组织的原理.
科学领域:
- 神经科学
- 大脑连接
- 系统神经科学
背景情况:
- 哺乳动物皮质是一个复杂的,层状结构,组织原理不太清楚.
- 现有关于大脑连接的知识缺乏其复杂网络的通用规则.
研究的目的:
- 扩展艾伦老鼠大脑连接图谱, 进行新的追踪实验.
- 推导出皮质皮质,皮质皮质和皮质皮质突起的通用解剖规则.
- 模拟和预测小鼠皮质体网络中的等级组织.
主要方法:
- 在小鼠皮层和脑丘脑中进行了大约一千项新的标志物实验.
- 使用CRE驱动线来对投影神经元类和层进行选择性标记.
- 开发了一个将连接模式分类为前或反的模型.
主要成果:
- 为主要的大脑投影类型推导了通用解剖规则.
- 分配到皮层和胸膜区域和网络模块的等级位置.
- 发现细胞类特定的连接在小鼠皮质体网络中形成了浅层层次结构.
结论:
- 建立了管理哺乳动物大脑连接的新通用原则.
- 为理解神经电路中的等级组织提供了一个预测模型.
- 在小鼠皮质层系统中展示了浅层层次的组织.
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