干细胞驱动的淋巴重塑协调组织再生
Shiri Gur-Cohen1, Hanseul Yang1, Sanjeethan C Baksh1
1Howard Hughes Medical Institute, Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA.
Science (New York, N.Y.)
|November 2, 2019
概括
淋巴毛细血管是干细胞 (SC) 利基的关键组成部分. SCs中的一个分泌基因开关控制了淋巴细胞的行为,影响了组织再生和毛囊循环.
科学领域:
- 干细胞生物学
- 组织再生
- 血管生物学
背景情况:
- 干细胞对于组织平衡和修复至关重要,存在于专门的微环境中.
- 在组织生长中SC的复杂作用仍在被阐明.
- 淋巴毛细血管尚未被广泛认为是关键的SC-niche组件.
研究的目的:
- 识别和描述淋巴毛细血管作为干细胞的关键组成部分的作用.
- 在组织再生过程中研究毛囊干细胞和淋巴毛细血管之间的动态相互作用.
- 解开干细胞调节淋巴细胞行为的分子机制.
主要方法:
- 使用小鼠模型研究干细胞与利基的相互作用.
- 研究毛囊干细胞的分泌物.
- 分析了淋巴毛细血管对干细胞信号的反应.
- 研究了淋巴干扰和分泌物干扰对毛囊循环和组织再生的影响.
主要成果:
- 识别了淋巴毛细血管作为毛囊干细胞的组成部分.
- 在干细胞中发现了一种分泌基因切换:静止基因切换表达血管类蛋白7 (Angptl7) 促进淋巴排水,而激活基因切换到血管类蛋白4 (Angptl4) 进行短暂的淋巴分离.
- 已经证明淋巴毛细血管或干细胞分泌物的干扰会导致毛囊早期循环和异步组织再生.
结论:
- 淋巴毛细血管是干细胞的重要组成部分,可动态调节组织再生.
- 干细胞分泌物通过特定的血管蛋白控制淋巴细胞的行为并影响组织修复过程.
- 了解这些SC - 淋巴相互作用可以了解协调干细胞活动以有效地再生组织.
相关概念视频
01:01Regulation of Hematopoietic Stem Cells
3.8K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.8K
01:21Stem Cell Therapy for Tissue Regeneration
4.5K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.5K
01:21Lineage Commitment
4.0K
Commitment is the process whereby stem cells:
4.0K
01:19Multipotency of Hematopoietic Stem Cells
3.7K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.7K
01:15Development of the Lymphatic System
1.9K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
1.9K
01:18Lymphoid Cells and Tissues
2.8K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
2.8K