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Selective Capture of 5-hydroxymethylcytosine from Genomic DNA
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用胺DNA糖酶切除5 - 碳基细胞素

Lakshmi S Pidugu1, Qing Dai2, Shuja S Malik1

  • 1Department of Biochemistry and Molecular Biology , University of Maryland School of Medicine , Baltimore , Maryland 21201 , United States.

Journal of the American Chemical Society
|November 7, 2019
PubMed
概括

结构洞察力揭示了丁氨酸DNA糖酶 (TDG) 如何切除5 - 碳素细胞素 (caC),这是活性DNA脱甲基化的关键步骤. 这阐明了表观遗传调节和疾病研究的酶机制.

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