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通过对NMR扩散数据的多线性分析,揭示了 Amyloid Fibril 形成过程中的明确可溶性状态

Kristine Steen Jensen1, Sara Linse2, Mathias Nilsson3

  • 1Biophysical Chemistry, Center for Molecular Protein Science, Department of Chemistry , Lund University , P.O. Box 124, SE-22100 Lund , Sweden.

Journal of the American Chemical Society
|November 9, 2019
PubMed
概括

研究人员使用扩散NMR和多线性分析在人体超氧化物脱酶1 (SOD1) 聚合过程中识别过渡性寡合物种,为神经退行性疾病机制提供了洞察力.

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相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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