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这页已由机器翻译。其他页面可能仍然显示为英文。View in English
  1. 首页
  2. 研究领域
  3. 生物医学和临床科学
  4. 瘤学和致癌症
  5. 预测和预后标志物
  6. 在慢性病患者中,巴克洛芬与脑病的相关性

在慢性病患者中,巴克洛芬与脑病的相关性

Flory T Muanda1,2, Matthew A Weir1,2,3, Lavanya Bathini1,3

  • 1Institute for Clinical Evaluative Sciences, London, Ontario, Canada.

JAMA
|November 10, 2019

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在PubMed 上查看摘要

概括
此摘要是机器生成的。

在慢性病 (CKD) 的老年人中,更高剂量的巴克洛芬会增加脑病的风险. 这项研究发现,与较低剂量相比,每天服用巴克洛芬20毫克或更高剂量的脑病变发生率显著增加.

科学领域:

  • 肝脏病学
  • 神经学
  • 临床药理学

背景情况:

  • 巴克洛芬是一种肌肉松剂,与慢性病患者的脑病有关.
  • 之前的报道显示,在慢性病患者中,至少有30例巴克洛芬与脑病变相关.

研究的目的:

  • 为了比较30天内新处方高剂量 (≥20 mg/ 天) 和低剂量 (<20 mg/ 天) 的CKD患者的脑病变风险.
  • 在这一群体中,将巴克洛芬使用者与非使用者的脑病变风险进行比较.

主要方法:

  • 在加拿大安大略省 (2007-2018) 基于人口的回顾性队列研究,使用链接的医疗保健数据.
  • 包括15,942名患有慢性脏病的老年人 (≥66岁) (eGFR<60毫升/分钟/1.73米2,不接受透析).
  • 使用治疗权重的逆概率和修改的Poisson回归来分析结果.

主要成果:

  • 开始服用巴克洛芬剂量≥20 mg/ 天的患者与服用<20 mg/ 天的患者相比,患脑病入院的风险增加了3. 54倍 (1. 11% vs 0. 42%).
  • 脑病变的风险随着EGFR水平的降低而逐渐增加.
  • 与非使用者相比,使用巴克洛芬的脑病风险显著增加 (每天≥20毫克的RR为19. 8).

结论:

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  • 较高的巴克洛芬剂量与老年CKD患者30天脑病发病率的增加有关.
  • 这些发现表明需要与巴克洛芬的治疗益处对比剂量相关的风险.