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  1. 首页
  3. 研究领域
  5. 生物医学和临床科学
  7. 心血管医学和血液学
  9. 心脏病 (包括心血管疾病)
  11. 美国reduce-it:美国3146名随机患者的结果

美国REDUCE-IT:美国3146名随机患者的结果

Deepak L Bhatt1, Michael Miller2, Eliot A Brinton3

  • 1Brigham and Women's Hospital Heart & Vascular Center and Harvard Medical School, Boston, MA (D.L.B.).

Circulation
|November 12, 2019

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在PubMed 上查看摘要

概括
此摘要是机器生成的。

在美国患者中,Icosapent ethyl显著降低了心血管事件,在REDUCE- IT试验中显示出强大的风险降低. 这一发现支持对高风险个体的使用,包括所有死亡原因的好处.

科学领域:

  • 心血管医学
  • 临床试验
  • 药理学

背景情况:

  • 之前的试验表明患者对治疗的反应因地域不同而有所不同.
  • 在REDUCE- IT试验中,研究了icosapent乙烯对心血管风险的降低.
  • 一个小组分析侧重于美国患者,以澄清这一群体中的治疗疗效.

研究的目的:

  • 评估icosapent ethyl在美国患者中的特定益处.
  • 在美国的REDUCE- IT试验中,将icosapent乙烯与安慰剂的疗效进行比较.

主要方法:

  • 在REDUCE- IT试验中,随机选择了8179名患有高甘油和已确定的心血管风险因素的患者.
  • 参与者接受了icosapent乙烯 (4 g/ d) 或安慰剂.
  • 主要综合终点包括心血管死亡,心肌梗塞,中风,再血管或不稳定的心痛住院.

主要成果:

  • 总共分析了3146名美国患者,占试验队列的38. 5%.
  • 在美国患者中,icosapent ethyl显著降低了初级复合终点 (HR 0. 69) 和关键二次复合终点 (HR 0. 69).
  • 对心血管死亡,心肌梗塞,中风和全因死亡的风险有显著降低,对全因死亡的相互作用是显著的 (P=0. 02).

结论:

  • 美国患者在REDUCE- IT试验中经历了相当大的心血管风险降低.
  • 调查结果显示,在美国小组中,包括所有原因死亡率在内的益处特别强大.
  • 安全性和耐受性概况与整个研究群体一致.
关键词:
美国酸乙烯基脂肪酸,欧米茄三类脂质预防和控制三糖类

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