乳蛋白质组显示,巨型类是早期的分离型类
Frido Welker1, Jazmín Ramos-Madrigal2, Martin Kuhlwilm3
1Evolutionary Genomics Section, Globe Institute, University of Copenhagen, Copenhagen, Denmark. frido.welker@bio.ku.dk.
Nature
|November 15, 2019
概括
进化过程中与猩猩有联系, 这一发现阐明了大猿的进化,
科学领域:
- 古蛋白质组学
- 灵长类动物的进化
- 分子人类学
背景情况:
- 由于化石证据有限,Gigantopithecus blacki是一个来自东南亚的巨型普莱斯托纪人类,其进化关系不清楚.
- 之前的假设缺乏分子验证,
研究的目的:
- 为了确定黑巨与其他类人猿的进化关系.
- 在米奥森时代研究大猿族的分离时间.
主要方法:
- 从190万年前的黑牙中提取了古老的牙质蛋白序列.
- 分析蛋白质序列以建立基因关系和分歧时间.
主要成果:
- 巨型类被认为是猩猩 (Pongo) 的姐妹类,大约有1200万年前的共同祖先.
- 这项研究提供了最古老的哺乳动物蛋白质组数据,将古蛋白质组分析扩展到新的地理和时间领域.
- 假设alpha-2-HS-glycoprotein在Gigantopithecus的厚面膜冠的生物矿物化中的作用.
结论:
- 巨型猿与猩猩的分化是巨型猿的苗代辐射的一部分.
- 在具有挑战性的环境中重建牙质的古老蛋白质分析是可行的.
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