非编码RNA在瘤学中的作用
Frank J Slack1, Arul M Chinnaiyan2
1Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02215, USA; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.
Cell
|November 16, 2019
概括
非编码RNAs (ncRNAs) 是细胞活动的新发现调节剂,在癌症中起着至关重要的作用. 研究表明这些分子可能是致癌或瘤抑制剂,
科学领域:
- 癌症生物学
- 分子生物学
- 遗传学
背景情况:
- 从历史上看, 癌症研究优先考虑蛋白质编码基因.
- 最近的发现强调了非编码RNAs (ncRNAs) 在细胞过程中的重要调节作用.
研究的目的:
- 为了强调ncRNA参与癌症的不断发展的理解.
- 强调ncRNAs作为生物标志物和治疗点的日益增长的临床相关性.
主要方法:
- 对ncRNA研究的最新进展进行回顾.
- 对ncRNAs在瘤生成和瘤抑制中的双重作用的分析.
主要成果:
- 非编码RNAs (ncRNAs) 是一个多样化且普遍存在的分子类.
- 在癌症生物学中,ncRNA既具有致癌功能,也具有瘤抑制功能.
- 现在有数百个临床试验正在研究ncRNA.
结论:
- ncRNAs代表了癌症生物学研究的范式转变.
- ncRNAs的治疗和诊断潜力是显著的,并且正在扩大.
- 针对ncRNA的临床试验正在迅速增加,
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