控制食的神经元的遗传鉴定
Ling Bai1, Sheyda Mesgarzadeh1, Karthik S Ramesh2
1Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA.
Cell
|November 16, 2019
概括
迷走神经可以感知食物的摄入. 肠道机械受体, 而不是营养传感器, 强烈抑制大脑中的饥饿信号,
科学领域:
- 神经科学
- 胃肠病学
- 生理学
背景情况:
- 能量稳定依赖于感知食物摄入量.
- 神经检测肠道信号, 但关键的感觉神经元调节食仍未确定.
- 了解这些信号对于代谢研究至关重要.
研究的目的:
- 确定调节食物摄入的感觉神经元和信号.
- 绘制胃肠道内的细胞类型.
- 确定不同肠道因子在养行为中的作用.
主要方法:
- 特定于神经元的单细胞RNA测序.
- 分子分析以识别不同的细胞类型.
- 在下丘脑中进行外周刺激和中央电生理记录.
主要成果:
- 独特的分子标记识别了具有特定内化和功能的迷你神经元.
- 肠道机械受体,而不是营养感应的粘膜附带体,强烈影响食物摄入.
- 刺激肠道机械受体强烈抑制促进饥饿的AgRP神经元.
结论:
- 肠道机理受体在调节养行为中起着至关重要的作用.
- 这项研究确定了腹信号的关键神经通路.
- 在保持能量平衡方面, 挥发性神经元是至关重要的.
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