感应运动体验将视觉输入重新映射到定向方向网络
Yvette E Fisher1, Jenny Lu1, Isabel D'Alessandro1
1Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Nature
|November 22, 2019
概括
果使用
科学领域:
- 神经科学
- 动物的行为
背景情况:
- 草指南针神经元整合自动运动以估计方向.
- 视觉线索可以提高定位准确性,而R神经元则可以提供输入.
- 视觉暗示集成到指南针网络的机制尚不清楚.
研究的目的:
- 研究如何将视觉线索集成到Drosophila指南针神经元网络中.
- 确定R神经元对指南针神经元进行视觉输入的作用.
- 在指南针系统中阐明视觉处理的可塑性.
主要方法:
- 在Drosophila的体内全细胞记录.
- 一起进行成像.
- 探索改变虚拟现实环境.
主要成果:
- 视觉线索在指南针神经元中引起突触抑制,由R神经元介导.
- 指南针神经元表现出特定的视觉提示位置敏感性.
- 视觉上的阻碍模式随着环境的变化而重组,
结论:
- 视觉唤起的抑制的关联性长期突触抑郁是可塑性的基础.
- 这种可塑性使自我运动与外部线索相协调,
- 这些发现支持结合吸引力动态的关联性可塑性模型.
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