人类胚胎检查多基因特征的效用有限
Ehud Karavani1, Or Zuk2, Danny Zeevi3
1Braun School of Public Health and Community Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
Cell
|November 26, 2019
概括
胚胎选的特征如身高或智商提供了最小的遗传优势. 这种潜在的好处是有限的,即使有很多胚胎,强调需要在遗传选择中实现现实的期望.
科学领域:
- 人类遗传学
- 生殖技术
- 生物伦理学
背景情况:
- 多基因分数越来越多地解释了人类的复杂特征.
- 在植入前基因诊断的进步使胚胎查成为可能.
- 胚胎查的不清楚结果阻碍了伦理讨论.
研究的目的:
- 评估胚胎查复杂特征的潜在遗传收益.
- 将遗传收益定义为得分最高的胚胎与平均胚胎之间的差异.
- 评估胚胎数量和分数差异对潜在收益的影响.
主要方法:
- 使用理论模型.
- 进行模拟.
- 分析了现实世界的遗传数据.
主要成果:
- 随着查胚胎的数量逐渐增加,
- 通过多基因分数解释的较高方差,增益更显著.
- 目前的技术平均提高了身高2.5厘米,认知能力提高了2.5分,预测间隔很大.
结论:
- 从胚胎查中获得的高度和认知能力的平均遗传收益与当前的多基因评分技术相比较小.
- 在实践中,很大一部分得分最高的胚胎并没有产生最高的特征值.
- 对于围绕胚胎查的道德辩论来说,
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