桑德鱼眼中的瓜宁和7,8-二桑托特林反射晶体:晶体位置,组成和结构
Gan Zhang1, Anna Hirsch2, Guy Shmul3
1Department of Structural Biology , Weizmann Institute of Science , Rehovot 76100 , Israel.
Journal of the American Chemical Society
|November 26, 2019
概括
鱼眼含有独特的水晶层. 研究人员发现外层含有瓜宁,内层含有7,8-二松丁, 增强了眼的光敏感性.
科学领域:
- 生物物理
- 晶体学
- 鱼类学
背景情况:
- 鱼眼通常具有反射晶体层,通常被认为是关氨酸,有助于视力.
- 鱼 (Stizostedion lucioperca) 的眼睛具有独特的双层晶体结构.
研究的目的:
- 在Stizostedion lucioperca眼睛的两个不同的层中识别晶体成分.
- 阐明这些成分在增强视觉灵敏度中的晶体结构和功能.
主要方法:
- 使用X射线衍射 (XRD) 和电子衍射来分析晶体结构.
- 密度函数理论 (DFT) 计算模拟的晶体结构.
- 通过矩阵辅助激光脱离/离子化飞行时间 (MALDI-TOF) 和拉曼光谱分析了固态晶体组成.
主要成果:
- 证实外层的晶体是关氨酸.
- 内部层晶体,最初假设为xantopterin,被明确地确定为7,8-dihydroxanthopterin.
- 结构建模和XRD数据合适证实了7,8-二桑托特林晶体结构.
结论:
- 在Stizostedion lucioperca的眼睛中使用了不同的瓜和7,8-二松托晶层.
- 关氨酸晶体提供银色的反射表面,而7,8-二桑托特林晶体通过反射增强视网膜的光敏感性.
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