急性损伤
Claudio Ronco1, Rinaldo Bellomo2, John A Kellum3
1Department of Medicine, University of Padova, Padova, Italy; International Renal Research Institute of Vicenza, Vicenza, Italy; Department of Nephrology, San Bortolo Hospital, Vicenza, Italy.
Lancet (London, England)
|November 29, 2019
概括
急性损伤 (AKI) 影响10-15%的住院患者和超过50%的重症监护人员. 新的生物标志物和干预措施有望对这种复杂的疾病进行管理.
科学领域:
- 肝脏病学
- 危急护理医学
背景情况:
- 急性损伤 (AKI) 的特点是功能迅速下降,影响了大量住院和危急病患者.
- 慢性病可能会发展为慢性病,
- AKI的多样性,包括各种综合症,如败血症和心综合症,使诊断和治疗变得复杂.
研究的目的:
- 提供急性损伤 (AKI) 的概述,包括其定义,发病率和临床影响.
- 讨论新兴生物标志物在评估损伤和指导治疗策略中的作用.
- 考虑到临床背景和资源的可用性,审查目前的AKI管理方法.
主要方法:
- 关于急性损伤的最新研究和临床指南的文献综述.
- 在不同患者群体中分析AKI的发病率和流行率.
- 评估新损伤生物标志物的诊断和预后价值.
- 综合各种AKI干预措施的有效性.
主要成果:
- 艾滋病的发病率很高,特别是在重症监护室 (ICU) 超过50%.
- 生物标志物有助于改善艾滋病风险分层和个性化治疗.
- 尽管存在治疗争议,但越来越多的证据支持某些干预措施的联合使用.
结论:
- AKI是一种复杂的综合征,具有显著的发病率和死亡率,需要定制的治疗策略.
- 生物标志物对于早期检测和风险评估至关重要,并可能指导治疗.
- 虽然治疗的有效性各不相同,但结合的干预措施在 AKI 管理中越来越有好处.
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