AAAA-DDDD 四重H键辅助的离子相互作用:水中的坚固 bis ((guanidinium) /二碳酸盐异重复体
Yuren Sun1, Jun Gu1, Hongyu Wang1
1School of Materials Science and Engineering, Center for Supramolecular Chemistry and Catalysis, and Department of Chemistry , Shanghai University , 99 Shang-Da Road , Shanghai 200444 , China.
Journal of the American Chemical Society
|December 3, 2019
概括
新的合成分子在水中形成稳定的异构体,与DNA和RNA相互作用竞争. 这些构建块还可以形成水凝,显示出先进材料应用的潜力.
科学领域:
- 超分子化学 超分子化学
- 有机化学 有机化学
- 材料科学 材料科学 材料科学
背景情况:
- 在水溶液中稳定非共价相互作用对于开发新型分子系统至关重要.
- 设计模仿或超越生物核酸相互作用的结合亲缘关系的合成分子是一个重大挑战.
研究的目的:
- 合成和表征新的双二和亚克里丁-910H) 一衍生物二碳酸盐衍生物.
- 研究这些衍生物在水中形成稳定的异构体的能力.
- 探索这些结构作为超分子组件和水凝的构建块的潜力.
主要方法:
- 使用紫外线对光谱学定位来研究结合亲缘关系.
- 异热定位热量计 (ITC) 用于量化异氧化物形成的热力学参数.
- 进行了有机分子的合成和结构改造.
主要成果:
- 双胞胎二) 和阿克里丁-9) -一种衍生的二) 碳酸盐) 衍生物 (1a-c和2a-e) 已成功合成.
- 这些衍生物在水中形成具有高结合亲和度的异构体 (ΔG < -7 kcal mol−1,Ka > 105 M−1).
- 结合亲和力与最强的DNA或RNA三重组对相匹敌或超过.
- 纳入经过聚乙烯甘醇 (PEG) 装饰的基组,使得特定衍生物 (1b-2c) 的凝形成.
结论:
- 开发的合成衍生物有效地稳定了水性介质中的异构体,具有显著的结合亲和力.
- 这些分子作为构建复杂异重复体和功能性水凝的多功能构建块.
- 这些发现为设计仿生超分子材料和药物输送系统提供了新的途径.
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