编程药物递送动力学以使用DNA触控开关进行激活突发释放
Mingshu Xiao1, Wei Lai1, Fei Wang2
1Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering , East China Normal University , 500 Dongchuan Road , Shanghai 200241 , China.
Journal of the American Chemical Society
|December 3, 2019
概括
这项研究引入了一种新的DNA工程水凝 (SNAgel),用于精确的化疗. 通过SNAgels,可以控制癌细胞中的药物释放,从而提高治疗效率并减少副作用.
科学领域:
- 生物材料科学
- 纳米技术
- 药物输送系统
背景情况:
- 目前的智能药物输送系统 (DDS) 在向瘤细胞内的精确可控药物释放方面面临挑战.
- 在化疗中实现高传递效率和疗效仍然是一个重大障碍.
研究的目的:
- 开发一种由基因突变设计的球形核酸模板水凝 (SNAgel),用于现场激活化学疗法药物的突发释放.
- 为了实现精确和可控的药物释放动力学在向癌细胞.
主要方法:
- 使用DNA脚开关和杂交连锁反应 (HCR) 的工程 SNAgels.
- 为控制药物释放动力 (t1/2从60.52到5.49分钟) 设计的对联体特异性脚序列.
- 使用紧的DNA外进行伪装,延长血液循环并增强瘤向.
主要成果:
- 证明了可调节动力学的化学治疗有效载荷的活跃爆发释放.
- 在体内,SNAgels表现出延长的血液循环,有针对性的积累和有效的细胞进入.
- 在癌细胞系和携带瘤的小鼠中观察到抗癌活性显著增强.
结论:
- 用DNA工程的动力控制方法为开发先进的DDS提供了一种新策略.
- 作为癌症治疗的模式转换平台,
- 这种方法提供了精确的,按需的药物释放,以改善癌症治疗结果.
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