进步化化学为动和其他+3 f-元素,Am,Cm和La
Benjamin W Stein1, Amanda Morgenstern1, Enrique R Batista1
1Los Alamos National Laboratory , Los Alamos , New Mexico 87545 , United States of America.
Journal of the American Chemical Society
|December 4, 2019
概括
研究人员开发了一种新方法来表征针对性阿尔法疗法的动 (Ac) 化剂. 他们发现DOTP8-完全封装Ac3+和其他金属离子,显示出对体内应用的希望.
科学领域:
- 放射化学 放射化学是指辐射化学.
- 核医学就是核医学.
- 协调化学 协调化学
背景情况:
- 使用Actinium-225 (Ac) 的向阿尔法疗法在疾病治疗方面表现有前途.
- 一个关键的挑战是确定适合的化剂,以使Ac与体内应用相兼容.
- 人们对Ac协调化学的理解很差,这阻碍了化剂的设计.
研究的目的:
- 开发一种用复杂的化剂来表征Ac复合物的方法.
- 为了研究通过DOTP8-.对Ac3+的化.
- 为了更好地理解针对性阿尔法疗法的Ac化化学.
主要方法:
- 使用微克的Actinium-227 (Ac) 量对Ac复合物的表征.
- 使用了扩展X射线吸收细结构 (EXAFS),核磁共振 (NMR) 和密度功能理论 (DFT) 技术.
- 用美洲 (Am), (Cm) 和兰坦 (La) 离子进行比较研究.
主要成果:
- 通过DOTP8-.成功地描述了Ac3+通过DOTP8-.的化.
- 在DOTP8-宏循环中发现了M3+的完整封装 (M = Ac,Am,Cm,La).
- 计算结果表明M(DOTP) 5-复合体的高稳定性.
结论:
- 开发的方法允许使用小样本大小对具有复杂化剂的Ac复合体进行表征.
- DOTP8-有效合Ac3+,形成适合体内应用的稳定复合体.
- 这项研究为Ac协调化学提供了关键的见解,推动了针对性阿尔法疗法的开发.
更多相关视频
10:54Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
8.5K
10:10Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes
Published on: July 28, 2018
6.8K
相关概念视频
Nuclear Transmutation
20.3K
Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed...
20.3K
Complexation Equilibria: The Chelate Effect
1.1K
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
1.1K
EDTA: Chemistry and Properties
3.1K
Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
3.1K
Periodic Classification of the Elements
57.9K
The periodic table arranges atoms based on increasing atomic number so that elements with the same chemical properties recur periodically. When their electron configurations are added to the table, a periodic recurrence of similar electron configurations in the outer shells of these elements is observed. Because they are in the outer shells of an atom, valence electrons play the most important role in chemical reactions. The outer electrons have the highest energy of the electrons in an atom...
57.9K
Electron Affinity
42.6K
The electron affinity (EA) is the energy change for adding an electron to a gaseous atom to form an anion (negative ion).
42.6K
Metal-Ligand Bonds
23.6K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
23.6K
