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胸腔粉与胸腔管粉对患有恶性多流的患者中多流失率的影响:随机临床试验
Rahul Bhatnagar1,2, Hania E G Piotrowska3, Magda Laskawiec-Szkonter3
1Academic Respiratory Unit, University of Bristol, Bristol, United Kingdom.
通过胸腔镜进行粉和通过胸腔管进行粉显示出恶性多流失效率相似. 在这项研究中,两种用于管理MPE的交付方法之间没有显著差异.
科学领域:
- 肺病学
- 胸部手术
- 癌症学
背景情况:
- 恶性流 (MPE) 的治疗是复杂的.
- 石膏化是一种标准的治疗方法, 但最佳的输送方法缺乏可靠的证据.
- 这种变化影响了临床实践和MPE治疗的建议.
研究的目的:
- 在胸腔镜检查中比较粉与通过胸腔管的粉在诱导MPE患者的疗效.
- 确定胸腔镜使用的石粉是否优于床边的胸管使用.
主要方法:
- 这是一项开放的随机临床试验,涉及英国17家医院的330名参与者.
- 患有MPE的患者被随机分配到接受粉 (n=166) 或粉 (n=164).
- 在随机化后的90天内,主要结论是膜失效.
主要成果:
- 在90天内,囊的失败率为22% (36/ 161) 粉和24% (38/ 159) 粉 (经调整的OR,0. 91;P=.74).
- 两组之间没有观察到主要结果的统计学意义上的差异.
- 二次结果,包括疼痛,呼吸困难,生活质量和死亡率,也没有显著差异.
结论:
- 胸腔镜粉和胸管粉在实现恶性胸膜溢出时具有相似的有效性.
- 这项研究表明,这两种交付方法的临床结果没有显著差异.
- 试验可能不足以检测干预措施之间的微妙但具有临床意义的差异.
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