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Updated: Jan 2, 2026

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通过工程B细胞成熟来向选择HIV特异性抗体突变

Kevin O Saunders1,2,3, Kevin Wiehe4, Ming Tian5

  • 1Human Vaccine Institute and Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA. kevin.saunders@duke.edu barton.haynes@duke.edu alt@enders.tch.harvard.edu.

Science (New York, N.Y.)
|December 7, 2019
PubMed
概括

No abstract available in PubMed .

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Hybridoma Technology01:31

Hybridoma Technology

Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
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Commonly used fusion techniques — electroporation,...
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