生育治疗与儿童癌症风险之间的关联
Marie Hargreave1, Allan Jensen1, Merete Kjær Hansen2
1Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
JAMA
|December 11, 2019
概括
冷胚胎移植与儿童癌症的风险略高,包括白血病和交感神经系统瘤. 在本研究中,其他生育治疗没有显著的癌症关联.
科学领域:
- 生殖医学
- 儿童瘤学
- 流行病学
背景情况:
- 全球越来越多的婴儿在接受生育治疗后出生.
- 这些治疗对儿童癌症风险的潜在影响尚不清楚.
- 关联可能与特定药物,手术或潜在的不孕症有关.
研究的目的:
- 调查各种生育治疗与儿童癌症风险之间的联系.
- 区分与特定生育药物和辅助生殖技术相关的风险.
主要方法:
- 使用丹麦登记数据 (1996-2012年出生,1996-2015年后续调查) 的回顾性队列研究.
- 包括100多万儿童,其中2217人被诊断患有癌症.
- 分析了母亲使用生育药物和辅助生殖技术 (ART) 程序,并将结果与生育妇女所产生的孩子进行比较.
主要成果:
- 冷胚胎移植与儿童癌症的风险增加有关 (HR,2. 43).
- FET的风险增加主要与白血病和交感神经系统瘤有关.
- 对于其他生育治疗方法,包括生育药物和其他ART方法,没有发现统计学意义上的关联.
结论:
- 使用冷胚胎移植 (FET) 与儿童癌症风险的小但显著增加有关.
- 在研究中检查的其他生育治疗方法中没有观察到这种关联.
- 可能需要进一步的研究来了解FET与癌症相关的机制.
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