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由RIPK1的不可切割变体引起的主导性自身炎症性疾病

Panfeng Tao1, Jinqiao Sun2, Zheming Wu3

  • 1The MOE Key Laboratory of Biosystems Homeostasis & Protection, Life Sciences Institute, Zhejiang University, Hangzhou, China.

Nature
|December 13, 2019
PubMed
概括

在RIPK1 (受体交互蛋白激酶1) 中的基因变异会损害caspase-8裂变,导致自身炎症. 这导致RIPK1激活的增加,对细胞死亡的过敏,以及炎症反应的增加.

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