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Generation of a RIP1 Knockout U937 Cell Line Using the CRISPR-Cas9 System
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阻止RIPK1的酶分裂的突变导致自身炎症性疾病

Najoua Lalaoui1,2, Steven E Boyden3, Hirotsugu Oda4

  • 1The Walter and Eliza Hall Institute, Parkville, Victoria, Australia. lalaoui@wehi.edu.au.

Nature
|December 13, 2019
PubMed
概括

对胚胎发育和预防自身炎症综合征至关重要. 阻止这种分裂的突变会导致人类的严重炎症疾病和小鼠的胚胎死亡.

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