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高分辨率结构和抑制与精神分裂相关的假基因酶ULK4

Susmita Khamrui1, Peter M U Ung1,2, Cody Secor1

  • 1Department of Pharmacological Sciences , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.

Journal of the American Chemical Society
|December 17, 2019
PubMed
概括

研究人员确定了与精神分裂症相关的人类ULK4的结构. 尽管缺乏转移活性,但ULK4通过一种不寻常的Mg2+独立机制结合ATP,为神经精神疾病提供了新的治疗点.

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