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订制的半孔金属网络粒子

Zhixing Lin1, Jiajing Zhou1, Christina Cortez-Jugo1

  • 1ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, and Department of Chemical Engineering , The University of Melbourne , Parkville , Victoria 3010 , Australia.

Journal of the American Chemical Society
|December 19, 2019
PubMed
概括
此摘要是机器生成的。

研究人员开发了一种新的模板方法,使用聚合物立方体来制造半孔金属 (meso-MPN) 颗粒. 这些颗粒具有较大的孔隙,使其具有较高的蛋白质载荷和增强的酶活性,可用于催化和药物输送.

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科学领域:

  • 材料科学
  • 纳米技术
  • 化学工程

背景情况:

  • 半孔金属有机网络对于气体储存,分离,催化和药物输送有价值.
  • 合成大型有序介质通道 (>20 nm) 用于宏分子应用仍然是一个重大挑战.

研究的目的:

  • 开发一种新的策略,用于合成具有大型中介通道的有序中介孔金属颗粒.
  • 证明这些颗粒具有高蛋白负载和增强酶活性的能力.

主要方法:

  • 使用牺牲双立方网络聚合物立方体 (Im3̅m) 作为模板.
  • 合成的有序金属颗粒 (meso-MPN) 具有大孔单立方网络 (Pm3̅m,~40 nm).
  • 研究的蛋白质负载 (HRP,血红蛋白,IgG,GOx) 和酶活性保留 (HRP,GOx).

主要成果:

  • 实现了高蛋白负载,例如,葡萄糖氧化酶 (GOx) 的362毫克g−1,比商业SiO2高6倍.
  • 显示出高氧化酶 (HRP) 的保留活性 (~82%) 具有很好的可回收性 (在五个循环中至少13%的活性损失).
  • 蛋白质负载能力优于具有相似孔径的商业SiO2颗粒.

结论:

  • 立方体模板策略成功地产生了适合大分子封装的大型半导体粒子.
  • 与现有的材料相比,这些MPN粒子在蛋白质负载能力和酶稳定性/可回收性方面具有显著的优势.
  • 这种方法具有多功能性,可以使用丰富的多和金属离子来设计各种MPN粒子.