营养不良的双重负担:病因和对健康的后果
Jonathan C Wells1, Ana Lydia Sawaya2, Rasmus Wibaek3
1Childhood Nutrition Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK.
Lancet (London, England)
|December 20, 2019
概括
营养不良的双重负担源于一生中对营养不良和超重的暴露,通过生物和社会因素影响健康. 需要对全球营养和公共卫生政策进行系统性改变.
科学领域:
- 营养科学
- 公共卫生
- 生涯流行病学
背景情况:
- 从历史上看,营养不良是一个单独的问题:营养不良与超重/肥胖.
- 全球营养转型导致各种形式的营养不良增加.
- 越来越多的人在一生中承受着营养不良的双重负担.
研究的目的:
- 探索不同形式的营养不良在整个生命过程中的相互联系.
- 确定营养不良双重负担的生物和社会驱动因素.
- 提出减轻营养不良双重负担的战略.
主要方法:
- 对营养不良,营养过渡和生命轨迹的现有文献进行审查.
- 分析早期营养不良与晚期超重相关的生物学途径.
- 检查影响营养不良模式的社会和生态因素.
主要成果:
- 早期的营养不良跟随后来的超重会增加非传染性疾病的风险.
- 女性的DBM增加了分娩并发症的风险.
- 相互关联的生物途径 (肠道微生物组,炎症,代谢失调) 介导了DBM的影响.
- 社会因素 (饮食变化,体力活动) 和生态因素 (病原体负担) 影响一生营养不良.
结论:
- 减轻DBM需要在营养和公共卫生方面做出重大社会转变.
- 需要全面,持续和全球范围的干预措施.
- 解决营养不良的双重负担对于改善全球健康状况至关重要.
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