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Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
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微生物胆汁酸代谢物调节肠道RORγ+调节T细胞平衡

Xinyang Song1, Ximei Sun1, Sungwhan F Oh1,2

  • 1Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.

Nature
|December 27, 2019
PubMed
概括

肠道微生物组

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T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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