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感官附带蛋白保护疟疾载体免受甲状腺感染

Victoria A Ingham¹, Amalia Anthousi², Vassilis Douris^3,4

¹Vector Biology, Liverpool School of Tropical Medicine, Liverpool, UK. victoria.ingham@lstmed.ac.uk.

|December 27, 2019

概括

蚊子对杀虫剂的耐药性威胁着疟疾的控制. 在蚊子腿中发现的一种新发现的蛋白质 - - 感官附属蛋白2 (SAP2) - - 能够抵抗常见的杀虫剂 - - 甲.

科学领域:

昆虫学
分子生物学
公共卫生

背景情况:

甲酸浸的床在非洲显著减少了疟疾病例.
非洲蚊的抗毒性增加威胁着疟疾控制的进展.
了解抗虫剂的遗传和分子基础对于有效的病媒控制至关重要.

研究的目的:

在Anopheles gambiae中识别出新型甲状腺耐药性机制.
调查感官附录蛋白2 (SAP2) 在赋予抗虫剂的作用.
分析SAP2介导耐药性的遗传基础和人口层面的影响.

主要方法:

在耐火和易受蚊子种群中分析SAP2的表达.
在Anopheles gambiae中涉及SAP2基因沉默和过度表达的功能研究.
基因组分析以确定与SAP2相关的选择性扫描和遗传变异.

主要成果:

在抗杀虫剂的蚊子中,SAP2的表达率升高,并因 pyrethroid 暴露而引起.
SAP2静音恢复了甲状腺敏感性,而过度表达增强了耐药性.
基因组数据显示西非蚊子群体的SAP2位点附近有选择性的扫除,与增加的甲状腺抗性相关.

结论:

SAP2是Anopheles gambiae中 pyrethroid耐药性的关键媒介,可能通过直接与杀虫剂结合.
广泛增加的SAP2表达和相关的遗传变化对疟疾载体控制构成重大挑战.
这一发现突显出一种新的抗虫剂机制,

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