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Updated: Jan 1, 2026

Author Spotlight: Investigating the Motion Dynamics of the Eukaryotic Replisome Components at the Single-Molecule Level
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H2A.Z促进早期复制来源的许可和激活

Haizhen Long1,2, Liwei Zhang1, Mengjie Lv3

  • 1National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

Nature
|December 27, 2019
PubMed
概括

基因组变异H2A.Z通过招募SUV420H1来表观基因调节DNA复制起源,该SUV420H1沉积H4K20me2. 这种修改对于原产地识别复合体1 (ORC1) 的结合至关重要,确保有效的复制时间.

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An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork.   Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication...
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