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  3. 原子级纳米环 (a-nrs) 用于光声成像和光热/光动力治疗癌症的治疗剂
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  3. 原子级纳米环 (a-nrs) 用于光声成像和光热/光动力治疗癌症的治疗剂

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原子级纳米环 (A-NRs) 用于光声成像和光热/光动力治疗癌症的治疗剂

Yongji Wang1, Ningqiang Gong1, Yujie Li1

  • 1Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology , Tsinghua University , Beijing 100084 , China.

Journal of the American Chemical Society
|December 28, 2019

在PubMed 上查看摘要

概括
此摘要是机器生成的。

超薄硫化物纳米环为癌症治疗提供了双重方法. 这种新型纳米材料能够进行光声成像,并结合光热和光动力疗法,提高癌细胞的破坏性.

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科学领域:

  • 纳米技术
  • 生物医学工程
  • 材料科学

背景情况:

  • 光热疗法 (PTT) 和光动力疗法 (PDT) 是已知的癌症治疗方法.
  • 开发先进的纳米材料对于提高治疗效率和成像能力至关重要.

研究的目的:

  • 合成和描述用于癌症治疗的超薄硫纳米环 (S-MoOx A-NR).
  • 评估PEGylated S-MoOx A-NRs作为光声成像 (PAI) 的对比剂的潜力.
  • 通过S-MoOx A-NR研究PTT和PDT在体外和体内癌症治疗中的协同效应.

主要方法:

  • 合成原子级 (0.5纳米厚度) 的超薄硫氧化物纳米环.
  • 用聚乙烯糖醇 (PEG) 改变表面,形成PEG@S-MoOx A-NR.
  • 对NIR吸收,光热转换和反应性氧物种 (ROS) 的产生进行评估.
  • 在体外和体内评估癌细胞杀死功效和PAI的能力.

主要成果:

  • 在近红外 (NIR) 范围内,PEG@S-MoOx A-NR具有很高的吸收性.
  • 该纳米材料在NIR照射时有效产生热量 (光热转换) 和ROS.
  • 展示了敏感的光声学成像对比度.
  • 在体外实现显著的癌细胞死亡,并在体内抑制瘤生长.

    • 结论:

    • 在癌症治疗中,PEG@S-MoOx A-NRs是一个有前途的治疗药物.
    • PAI与协同PTT/PDT的结合为癌症治疗提供了一种新的策略.
    • 超薄 S-MoOx A-NR 显示了高级癌症治疗应用的潜力.