在生殖器部使用粉末与卵巢癌风险的关联
Katie M O'Brien1, Shelley S Tworoger2,3, Holly R Harris4,5
1Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.
JAMA
|January 8, 2020
概括
在一项大型研究中,生殖器粉末的使用与卵巢癌风险没有显著关联. 可能需要进一步的研究来排除微小的风险增加.
科学领域:
- 妇科瘤学
- 流行病学
- 公共卫生
背景情况:
- 性器粉使用与卵巢癌之间的联系尚不清楚.
- 之前的病例控制研究表明存在正面关联,但队列研究没有证实这一点.
- 需要前性数据来澄清这种关系.
研究的目的:
- 调查生殖器粉末使用与卵巢癌风险之间的关联.
- 利用来自美国大型群体的前性观察数据进行强有力的分析.
主要方法:
- 来自美国四大群体的数据汇总:护士健康研究,护士健康研究II,姐妹研究和妇女健康倡议观察研究.
- 评估了长期 (≥20年) 和频繁 (≥1/周) 的生殖器粉末使用.
- 使用考克斯的比例危险模型来估计与共变量调整的危险比率 (HRs) 和95%的置信区间 (CI).
主要成果:
- 分析包括252,745名妇女,其中38%报告使用生殖器粉.
- 在使用生殖器粉末和卵巢癌之间没有发现统计学意义上的关联 (HR,1. 08;95% CI,0. 99-1. 17).
- 对于频繁或长期使用,没有发现显著的关联,尽管该研究可能缺乏检测小风险的能力.
结论:
- 这项大型综合分析没有发现生殖器粉末使用与卵巢癌之间的统计学意义上的关联.
- 这项研究可能不足以检测出风险的微小增加.
- 需要进一步调查,最终排除任何潜在的联系.
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