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Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine
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Published on: February 26, 2019

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通过非激剂激活GLP-1受体

Peishen Zhao1, Yi-Lynn Liang1, Matthew J Belousoff1

  • 1Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

Nature
|January 10, 2020
PubMed
概括

一种新的非激动剂TT-OAD2与类似葡萄糖-1 (GLP-1) 受体结合,揭示了一个新的结合口袋. 这一发现改变了对B类G蛋白结合受体激活和偏差激应的理解.

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