在纠正先天性大动脉狭窄后,左心室几何,壁应力和喷射性能的变化
G W Dorn1, R Donner, M E Assey
1Department of Medicine, Medical University of South Carolina, Charleston 29425.
Circulation
|December 1, 1988
概括
在儿童中,手术纠正先天性大动脉狭窄症使左心室壁应力正常化. 然而,左心室质量保持不变,外射性能在手术后下降.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 心血管外科心血管外科
- 生物医学工程 生物医学工程
背景情况:
- 儿童先天性大动脉狭窄导致左心室过度增大和减少壁压力,保持超正常的喷射性能.
- 如果大动脉狭窄症没有得到纠正,这种过度缩模式会持续到成年期.
研究的目的:
- 研究缓解大动脉压梯度对患有先天性大动脉狭窄症的儿童左心室缩和壁压力的影响.
- 测试一下大动脉门的更换或修复是否通过消除高的刺激来使左心室质量和壁面应力正常化.
主要方法:
- 一项前性研究,测量左心室喷射性能,壁应力和收缩功能.
- 七名儿科患者在先天性大动脉狭窄的手术纠正前和36 +/- 7个月后接受了心脏导管治疗.
主要成果:
- 大动脉梯度和峰值左心室压力在手术后显著下降.
- 左心室喷射率和周围纤维缩短的速度在术后下降.
- 左心室质量保持不变,但相对于半径的壁厚明显减少.
结论:
- 手术纠正使先天性大动脉狭窄症儿童的左心室壁应力正常化.
- 虽然左心室质量没有变化,但墙壁应力正常化是关键结果.
- 手术后降低射出性能需要进一步研究长期功能影响.
相关概念视频
Mitral Regurgitation I: Introduction
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Mitral Stenosis I: Introduction
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Aortic Regurgitation I: Introduction
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Heart Failure II: Pathophysiology
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...


