通过脊柱替换的β-的多个脊柱二面角的每残余程序
Jumpei Morimoto1, Jungyeon Kim1, Daisuke Kuroda1,2
1Department of Chemistry and Biotechnology, Graduate School of Engineering , The University of Tokyo , 7-3-1 Hongo , Bunkyo-ku , Tokyo 113-8656 , Japan.
Journal of the American Chemical Society
|January 10, 2020
概括
研究人员开发了一种新方法来控制合成聚合物的折叠,称为N替代β- (或β-). 这种策略使它们的结构能够精确编程,从而产生独特的形状,并促进新型功能折叠结构的发现.
科学领域:
- 合成化学
- 聚合物科学
- 结构生物学
背景情况:
- 有机体的独特功能是由它们的折叠结构决定的.
- 由于模块化合成,N替代β- (β-) 是合成的寡合体,具有多样化的3D结构的潜力.
- 由于多个可旋转的键,控制β-的构造具有挑战性.
研究的目的:
- 开发β-peptoids中二面角的每余量编程策略.
- 为了限制β-的形状空间以控制折叠.
- 在合成寡合物中发现新的折叠结构.
主要方法:
- 在β-peptoids中编程两个二面角的新策略.
- 使用循环二重化和NMR光谱进行结构分析.
- 进行X射线晶体分析以确定寡合物的结构.
主要成果:
- 开发的策略成功地限制了β-的构造空间.
- 寡合物采用独特的循环形状,由脊柱旋转限制稳定.
- 通过光谱和晶体分析证实了独特的折叠结构.
结论:
- 通过对二面角的残余编程来控制β-形状的新策略已建立.
- 这种方法有助于形成独特的稳定循环结构.
- 这种方法有助于发现β-的多样化和新的折叠结构.
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