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相关概念视频

Gastrulation01:56

Gastrulation

65.3K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
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Neurulation01:30

Neurulation

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Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
44.8K
Determining the Plane of Cell Division02:13

Determining the Plane of Cell Division

3.7K
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division...
3.7K
Cleavage and Blastulation01:33

Cleavage and Blastulation

49.5K
After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
49.5K

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相关实验视频

Updated: Dec 31, 2025

Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development
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Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development

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沿中线轴的编程细胞死亡模式

Lisandro Maya-Ramos1, Takashi Mikawa2

  • 1Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.

Science (New York, N.Y.)
|January 11, 2020
PubMed
概括

通过将细胞保持在自己的侧面来保持双边对称性. 胚胎中线上的细胞外基质和编程细胞死亡阻止细胞的交叉,确保双侧发育.

科学领域:

  • 发育生物学
  • 进化生物学
  • 细胞生物学

背景情况:

  • 双边对称是动物的主导体位,左侧和右侧通常保持分开.
  • 精确的机制编程这个保存的身体计划,特别是在早期的发展,并没有完全理解.

研究的目的:

  • 研究如何在鸟类胃化过程中实现胚胎层模式.
  • 确定抑制对侧细胞入侵并维持胚胎中线的因素.

主要方法:

  • 研究鸟类胃流动以观察细胞迁移和模式.
  • 在胚胎中线上操纵细胞外基质 (ECM) 和编程细胞死亡 (PCD).
  • 评估了这些操作对ipsilateral gastrulation的影响.

主要成果:

  • 尽管有侵入性细胞行为,但鸟类胃流中的细菌层模式是异侧的.
  • 在中线的细胞外基质 (ECM) 和编程细胞死亡 (PCD) 能积极抑制对侧细胞的侵入.
  • 抑制中线ECM和PCD干扰了ipsilaterality,通过诱导PCD恢复了这种功能.

结论:

  • 双边性是进化保存的双边性的关键组成部分.

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  • 编程细胞死亡 (PCD) 在建立和维持发育不对称方面发挥着至关重要的积极作用.
  • 了解这些机制可以了解发育障碍和进化过程.