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相关概念视频

Crystal Growth: Principles of Crystallization01:25

Crystal Growth: Principles of Crystallization

4.5K
Crystallization is a phase transformation process in which crystals are precipitated from a supersaturated solution or formed from other sources. During crystallization, atoms or molecules arrange themselves into a well-defined, rigid crystal lattice to minimize energy.
Initiating crystallization involves manipulating the concentration of the solute and the temperature of the solution. Since crystal growth occurs when the ratio of concentration and solubility of the solute in the solvent...
4.5K
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

8.6K
Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
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Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

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Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

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Crystal Field Theory - Octahedral Complexes02:58

Crystal Field Theory - Octahedral Complexes

30.2K
Crystal Field Theory
To explain the observed behavior of transition metal complexes (such as colors), a model involving electrostatic interactions between the electrons from the ligands and the electrons in the unhybridized d orbitals of the central metal atom has been developed. This electrostatic model is crystal field theory (CFT). It helps to understand, interpret, and predict the colors, magnetic behavior, and some structures of coordination compounds of transition metals.
CFT focuses on...
30.2K
Cationic Chain-Growth Polymerization: Mechanism00:57

Cationic Chain-Growth Polymerization: Mechanism

2.7K
The cationic polymerization mechanism consists of three steps: initiation, propagation, and termination. In the initiation step of the polymerization process, the π bond of a monomer gets protonated by the Lewis acid catalyst, which is formed from boron trifluoride and water. The protonation of the π bond generates a carbocation stabilized by the electron‐donating group. In the propagation step, the π bond of the second monomer acts as a nucleophile and attacks the...
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相关实验视频

Updated: Dec 30, 2025

Optimization of Crystal Growth for Neutron Macromolecular Crystallography
12:29

Optimization of Crystal Growth for Neutron Macromolecular Crystallography

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晶体生长修饰剂之间的对抗性合作

Wenchuan Ma1, James F Lutsko2, Jeffrey D Rimer3,4

  • 1Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX, USA.

Nature
|January 17, 2020
PubMed
概括

两种抑制剂可以协同或对抗地阻断晶体的生长,这取决于它们的特定机制和度. 这一发现为复杂系统中的结晶控制提供了新的策略.

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Optimizing the Growth of Endothiapepsin Crystals for Serial Crystallography Experiments
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Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering
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科学领域:

  • 结晶科学
  • 材料科学
  • 生物物理

背景情况:

  • 多元组件环境的结晶在自然界和工业中很常见.
  • 实验室研究主要集中在纯溶液结晶和单增长修饰剂上.
  • 了解结晶修饰剂对于控制材料合成和生物过程至关重要.

研究的目的:

  • 研究阻断血结晶的双抑制剂的分子机制.
  • 探索不同结晶修饰剂之间的协同作用和对抗作用.
  • 为指导材料合成发展结晶变异剂相互作用的分子观点.

主要方法:

  • 使用扫描探针显微镜 (SPM) 来观察分子水平上的晶体生长.
  • 采用分子建模来模拟和理解抑制剂-晶体相互作用.
  • 检查了具有明显机制的抑制剂对:扭曲阻断和步骤固定.

主要成果:

  • 在阻断血结晶方面,抑制剂对表现出协同作用和对抗作用.
  • 合作性取决于特定的抑制剂组合及其应用度.
  • 发现曲阻断剂可以降低步边线的张力,促进晶体层的核和传播.

结论:

  • 目前的晶体生长模型并没有捕捉到晶体修饰剂之间的对抗性合作.
  • 对修饰剂相互作用的分子理解为材料合成中的修饰剂配对提供了指导.
  • 这些发现提供了复杂的自然和工程系统中控制结晶的策略.