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Updated: Dec 30, 2025

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乳腺癌的单细胞病理景观

Hartland W Jackson1,2, Jana R Fischer1,2,3, Vito R T Zanotelli1,2,3

  • 1Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.

Nature
|January 22, 2020
PubMed
概括

这项研究使用成像质细胞计分析乳腺癌组织,揭示了与患者存活相关的新子组. 空间分辨的单细胞分析提供了个性化癌症诊断的潜力.

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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