在接受重大腹部手术的高风险患者中,基乙与盐酸替代疗法对死亡或术后并发症的影响:FLASH随机临床试验
在PubMed上查看摘要
概括
此摘要是机器生成的。在重大腹部手术后预防死亡或并发症方面,基乙 (HES) 溶液与0. 9%盐水没有显著差异. 这些发现表明HES不建议在高风险的手术患者中进行液体替代.
科学领域
- 麻醉学
- 危急护理医学
- 手术的结果
背景情况
- 在高风险的手术患者中,基乙醇粉 (HES) 溶液的安全性和有效性尚不清楚.
- HES是一种用于纠正血管内缺陷的合溶液.
研究的目的
- 为了比较HES130/0.4和0.9%盐水对死亡率和术后并发症的影响.
- 评估患有损伤风险的重大腹部手术患者的补液策略.
主要方法
- 这是一项多中心,双盲,随机临床试验,涉及775名接受重大腹部手术的成年患者.
- 患者接受 6% HES 130/ 0. 4 盐水或单纯盐水以扩大体积.
- 评估结果包括14天死亡或重大并发症和28天和90天的死亡率.
主要成果
- 在HES和盐溶液组之间没有发现主要结果 (死亡或重大并发症组合) 的显著差异 (36%对32%).
- 在12个预先指定的次要结果中,有11个组之间没有显著差异.
- 在第一天服用液体的中位数中发现了统计学上显著的差异,HES组接受的液体较少.
结论
- 在减少死亡或重大术后并发症方面,基乙 (HES) 130/ 0. 4与0. 9%盐水没有表现出优势.
- 研究结果不支持在患有损伤风险的腹部重大手术患者中使用HES进行体积替代疗法.
- 可能需要进一步的研究来澄清HES在特定患者群体或手术环境中的作用.
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