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四个质细胞通过神经信号在C中调节ER的抗压和长寿. 优雅的

Ashley E Frakes^1,2, Melissa G Metcalf^1,2, Sarah U Tronnes^1,2

¹Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.

Science (New York, N.Y.)

|January 25, 2020

概括

质细胞可以通过激活远处细胞的应激反应来延长寿命. 这项研究表明,在质细胞中激活未折叠蛋白质反应 (UPR^ER) 会增强对蛋白质聚合和ER压力的抵抗力.

科学领域:

神经科学
细胞生物学
老龄化研究

背景情况:

蛋白质平衡对于健康至关重要,
展开的蛋白质反应 (UPR^ER) 减轻了内质网膜的压力,但随着年龄的增长而下降.

研究的目的:

研究星状细胞在生物体抗压力和长寿中的作用.
确定细胞内UPR^ER的激活是否会影响衰老和蛋白质稳定.

主要方法:

在*C. elegans*的星形细胞中表达了构成性活跃的XBP-1s (一种UPR^ER转录因子).
估计寿命,蛋白质聚合,以及ER应激性.
在神经处理和分泌中使用突变物.

主要成果:

质XBP-1s的表达延长了生物体的寿命.
在远端细胞中激活UPR^ER (细胞非自主效应).
增加对蛋白质聚合和慢性ER压力的抵抗力.
神经处理突变导致质UPR^ER的诱导和寿命延长.

结论:

类似星细胞的质细胞在调节生物体的ER抗压力和寿命方面发挥着至关重要的作用.
质衍生信号介导细胞非自主UPR激活.
针对质功能可以提供与年龄相关的抗衰减策略.

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